New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells

Drug resistance is an important open problem in cancer treatment. In recent years, the heat shock protein HSP27 (HSPB1) was identified as a key player driving resistance development. HSP27 is overexpressed in many cancer types and influences cellular processes such as apoptosis, DNA repair, recombin...

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Bibliographic Details
Published in:Oncotarget 2016-10, Vol.7 (42), p.68156-68169
Main Authors: Heinrich, Jörg C., Donakonda, Sainitin, Haupt, V. Joachim, Lennig, Petra, Zhang, Yixin, Schroeder, Michael
Format: Article
Language:English
Subjects:
Antipsychotic Agents - chemistry
Antipsychotic Agents - pharmacology
Apoptosis - drug effects
Cell Line, Tumor
Chlorpromazine - chemistry
Chlorpromazine - pharmacology
Computational Biology - methods
Cytostatic Agents - chemistry
Cytostatic Agents - pharmacology
Drug Repositioning - methods
Drug Resistance, Neoplasm - drug effects
HSP27 Heat-Shock Proteins - antagonists & inhibitors
HSP27 Heat-Shock Proteins - metabolism
Humans
Molecular Docking Simulation
Molecular Structure
Neoplasms - metabolism
Neoplasms - pathology
Protein Binding
Research Paper
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