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In vivo assessment of possible probiotic properties of Zymomonas mobilis in a Wistar rat model
In recent years the incorporation of probiotic bacteria into foods has received increasing scientific interest for health promotion and disease prevention. The safety and probiotic properties of Zymomonas mobilis CP4 (UFPEDA-202) was studied in a Wistar rat model fed the 109 colony forming units (cf...
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Published in: | Electronic Journal of Biotechnology 2010-03, Vol.13 (2) |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | In recent years the incorporation of probiotic bacteria into foods has
received increasing scientific interest for health promotion and
disease prevention. The safety and probiotic properties of Zymomonas
mobilis CP4 (UFPEDA-202) was studied in a Wistar rat model fed the
109 colony forming units (cfu)/mL-1 of the assayed strain for 30 days.
No abnormal clinical signs were noted in the group receiving viable
cells of Z. mobilis and water (control) during the period of the
experiment. There were no significant difference (p > 0.05) in feed
intake and weight gain among mice fed the Z. mobilis in comparison to
the control group. No bacteria were found in blood, liver and spleen of
any animals. Mice receiving Z. mobilis showed significantly differences
(p < 0.05) in total and differential leucocytes count, excepting for
neutrophils, after the experimental period. Otherwise, it was not found
in control group. Histological examination showed that feeding mice
with Z. mobilis caused no signs of adverse effects on gut, liver and
spleen. From these results, Z. mobilis CP4 (UFEPEDA-202) is likely to
be nonpathogenic and safe for consumption, and could have a slight
modulating effect on immunological performance in mice. |
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ISSN: | 0717-3458 0717-3458 |
DOI: | 10.2225/vol13-issue2-fulltext-4 |