Interferon-γ gene and interferon-γ receptor-1 gene polymorphisms in children with tuberculosis from Turkey

• Published in: Scandinavian journal of infectious diseases 2010, Vol.42 (1), p.39-42
• Main Authors: Onay, Huseyin, Ekmekci, Aslihanyilmaz, Durmaz, Burak, Sayin, Eren, Cosar, Hese, Bayram, Nuri, Can, Demet, Akin, Haluk, Ozkinay, Cihangir, Ozkinay, Ferda
• Format: Article
• Language: English
• Subjects: Bacterial diseases; Biological and medical sciences; Case-Control Studies; Child; Child, Preschool; Female; Gene Frequency; Genotype; Human bacterial diseases; Humans; Infectious diseases; Interferon gamma Receptor; Interferon-gamma - genetics; Male; Medical sciences; Polymorphism, Genetic; Receptors, Interferon - genetics; Tuberculosis - genetics; Tuberculosis and atypical mycobacterial infections; Turkey
• ISSN: 0036-5548; 1651-1980
• DOI: 10.3109/00365540903253502

Abstract Macrophage activation by interferon-γ (IFN-γ) is important in host resistance to tuberculosis (TB). In this study, the relationships of the +874 T/A polymorphism in the first intron of the IFN-γ gene and intronic (CA)n polymorphic microsatellite marker of the interferon-γ receptor 1 (IFN-γR1) gene to TB susceptibility were investigated in children. Forty children with TB and 67 age-matched controls were included. There were no significant differences between the allele frequencies and genotype frequencies of patient and control groups for the polymorphism +874 T/A in the IFN-γ gene. Differences that were not statistically significant were found between the group of children with TB and the control group for the allelic markers (170 and 180) in the IFN-γR1 gene. The incidence of the allele 170 was higher in patients (30.9%) than in controls (17.4%), whereas the allele 180 was found to be more common in controls (9% vs 1.2%). In conclusion, no significant association was observed between the +874 T/A polymorphism found in the first exon of the IFN-γ gene and TB susceptibility in Turkish children.