Synthetic lung surfactant reduces alveolar-capillary protein leakage in surfactant-deficient rabbits

ABSTRACTPurpose of the Study: Alveolar-capillary leakage of proteinaceous fluid impairs alveolar ventilation and surfactant function and decreases lung compliance in acute lung injury. We investigated the correlation between lung function and total protein levels in bronchoalveolar lavage fluid (BAL...

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Bibliographic Details
Published in:Experimental lung research 2015-06, Vol.41 (5), p.293-299
Main Authors: Gupta, Rohun, Hernández-Juviel, José M., Waring, Alan J., Walther, Frans J.
Format: Article
Language:English
Subjects:
alveolar-capillary leakage
Animals
bronchoalveolar lavage fluid
Bronchoalveolar Lavage Fluid - chemistry
Lung - drug effects
Lung - metabolism
Lung Compliance - drug effects
lung function
Oxygen - metabolism
Peptides - metabolism
protein
Proteins - metabolism
Pulmonary Alveoli - drug effects
Pulmonary Alveoli - metabolism
Pulmonary Surfactants - pharmacology
Rabbits
Respiration, Artificial - methods
surfactant
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Summary:ABSTRACTPurpose of the Study: Alveolar-capillary leakage of proteinaceous fluid impairs alveolar ventilation and surfactant function and decreases lung compliance in acute lung injury. We investigated the correlation between lung function and total protein levels in bronchoalveolar lavage fluid (BALF) of ventilated, lavaged surfactant-deficient rabbits treated with various clinical and synthetic lung surfactant preparations. Materials and Methods: 109 ventilated, young adult New Zealand White rabbits underwent lung lavage to induce surfactant-deficiency (PaO2 200 torr. Fourteen non-responders received inactive surfactant preparations. BALF protein levels were inversely correlated with PaO2 and lung compliance (P < .001). Surfactant preparations containing both SP-B and SP-C proteins or peptide analogs outperformed single protein/peptide preparations. Conclusions: Clinical and synthetic surfactant therapy reduces alveolar-capillary protein leakage in surfactant-deficient rabbits. Surfactant preparations with both SP-B and SP-C (analogs) were more efficient than preparations with SP-B or SP-C alone.
ISSN:0190-2148
1521-0499
DOI:10.3109/01902148.2015.1024354