Chronic Lead Exposure Effects in the Cynomolgus Monkey (Macaca fascicularis) Testis

Although reproductive consequences of high circulating blood lead levels (≥60 μg/dL) have been reported, potential adverse effects of chronic lead exposure in males that result in low to moderate blood lead levels (10-25 and 26-60 μg/dL, respectively) are unknown. Effects of chronic lead exposure to...

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Bibliographic Details
Published in:Ultrastructural pathology 1998, Vol.22 (1), p.63-71
Main Authors: Foster, Warren G., Singh, Amreek, McMahon, Avril, Rice, Deborah C.
Format: Article
Language:English
Subjects:
Animals
cynomolgus monkey
Disease Models, Animal
electron microscopy
Follicle Stimulating Hormone - blood
lead
Lead Poisoning - blood
Lead Poisoning - physiopathology
Luteinizing Hormone - blood
Macaca fascicularis - blood
Male
Microscopy, Electron
Semen - drug effects
seminiferous epithelium
Testis - drug effects
Testis - ultrastructure
Testosterone - blood
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Summary:Although reproductive consequences of high circulating blood lead levels (≥60 μg/dL) have been reported, potential adverse effects of chronic lead exposure in males that result in low to moderate blood lead levels (10-25 and 26-60 μg/dL, respectively) are unknown. Effects of chronic lead exposure to testis ultrastructure were determined in the cynomolgus monkey after oral administration of lead acetate (1500 μg/kg BW/day) in a vehicle in the following groups: from birth to 10 years (lifetime), postnatal day 300 to 10 years (postinfancy), and postnatal day 0-400 (infancy); monkeys in the control group only the vehicle (95% glycerol and 5% distilled water). At age 10 years, circulating lead concentrations in lifetime and postinfancy-dosed monkeys were approximately 35 ug/dL, and in control and infancy animals the concentrations were
ISSN:0191-3123
1521-0758
DOI:10.3109/01913129809032259