PROCALCITONIN AND C-REACTIVE PROTEIN SERUM LEVELS AS MARKERS OF INFECTION IN A PEDIATRIC POPULATION WITH FEBRILE NEUTROPENIA AND CANCER

Background: Procalcitonin and C-reactive-protein are inflammatory markers for sepsis. The authors evaluated their sensitivity and specificity in pediatric patients with cancer and febrile neutropenia. Procedure: Serum procalcitonin and C-reactive-protein were evaluated. Patients (n = 54) were divide...

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Published in:Pediatric hematology and oncology 2009-09, Vol.26 (6), p.414-425
Main Authors: Martinez-Albarran, Manuel, de Jesus Perez-Molina, Jose, Gallegos-Castorena, Sergio, Sanchez-Zubieta, Fernando, Del Toro-Arreola, Susana, Troyo-Sanroman, Rogelio, Gonzalez-Ramella, Oscar
Format: Article
Language:English
Subjects:
Adolescent
Bacteria - pathogenicity
Bacterial Infections - blood
Bacterial Infections - epidemiology
Bacterial Infections - microbiology
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Calcitonin - blood
Calcitonin Gene-Related Peptide
Child
Child, Preschool
febrile neutropenia
Female
Humans
Infant
Infant, Newborn
infection marker
Male
Mexico - epidemiology
Neoplasms - blood
Neoplasms - epidemiology
Neoplasms - microbiology
Neutropenia - blood
Neutropenia - epidemiology
Neutropenia - microbiology
procalcitonin
Prognosis
Prospective Studies
Protein Precursors - blood
ROC Curve
Sensitivity and Specificity
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Summary:Background: Procalcitonin and C-reactive-protein are inflammatory markers for sepsis. The authors evaluated their sensitivity and specificity in pediatric patients with cancer and febrile neutropenia. Procedure: Serum procalcitonin and C-reactive-protein were evaluated. Patients (n = 54) were divided into 2 groups, with severe infection (n = 18) or without documented infection (n = 36). Results: Procalcitonin and C-reactive protein were significantly higher in the high-risk group. Procalcitonin displayed 72.2% sensitivity and 80.5% specificity. C-reactive-protein had a sensitivity of 77.7% and specificity of 77.2%. Conclusions: Procalcitonin is an accurate predictor of bacterial infection in neutropenic children, while C-reactive-protein may be a better screening test in emergency settings.
ISSN:0888-0018
1521-0669
DOI:10.3109/08880010903044797