Effect of pre- and postnatal exposure to urban air pollution on myocardial lipid peroxidation levels in adult mice

Exposure to air pollution can elicit cardiovascular health effects. Children and unborn fetuses appear to be particularly vulnerable. However, the mechanisms involved in cardiovascular damage are poorly understood. It has been suggested that the oxidative stress generated by air pollution exposure t...

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Published in:Inhalation toxicology 2009-11, Vol.21 (13), p.1129-1137
Main Authors: Damaceno-Rodrigues, Nilsa Regina, Veras, Mariana Matera, Negri, Elnara Márcia, Zanchi, Ana Claudia Tedesco, Rhoden, Claudia Ramos, Saldiva, Paulo Hilário Nascimento, Dolhnikoff, Marisa, Caldini, Elia Garcia
Format: Article
Language:English
Subjects:
Aging - drug effects
Aging - pathology
Air pollution
Air Pollution - adverse effects
Animals
Animals, Newborn
Female
heart
Inhalation Exposure - adverse effects
lipid peroxidation
Lipid Peroxidation - drug effects
Lipid Peroxidation - physiology
Male
Mice
Mice, Inbred BALB C
Myocardium - metabolism
Myocardium - pathology
oxidative stress
particulate matter
Pregnancy
Prenatal Exposure Delayed Effects - metabolism
Prenatal Exposure Delayed Effects - pathology
Urban Health
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Summary:Exposure to air pollution can elicit cardiovascular health effects. Children and unborn fetuses appear to be particularly vulnerable. However, the mechanisms involved in cardiovascular damage are poorly understood. It has been suggested that the oxidative stress generated by air pollution exposure triggers tissue injury. To investigate whether prenatal exposure can enhance oxidative stress in myocardium of adult animals, mice were placed in a clean chamber (CC, filtered urban air) and in a polluted chamber (PC, São Paulo city) during the gestational period and/or for 3 mo after birth, according to 4 protocols: control group-prenatal and postnatal life in CC; prenatal group-prenatal in PC and postnatal life in CC; postnatal group-prenatal in CC and postnatal life in PC; and pre-post group-prenatal and postnatal life in PC. As an indicator of oxidative stress, levels of lipid peroxidation in hearts were measured by malondialdehyde (MDA) quantification and by quantification of the myocardial immunoreactivity for 15-F2t-isoprostane. Ultrastructural studies were performed to detect cellular alterations related to oxidative stress. Concentration of MDA was significantly increased in postnatal (2.45 ± 0.84 nmol/mg) and pre-post groups (3.84 ± 1.39 nmol/mg) compared to the control group (0.31 ± 0.10 nmol/mg) (p 
ISSN:0895-8378
1091-7691
DOI:10.3109/08958370902798430