Salmonella brain abscess in a patient on chronic azathioprine therapy for myasthenia gravis: report of an unusual case and review of literature in the postantibiotic era

Focal intracranial infections caused by Salmonella species in adults are exceedingly uncommon. Structural brain injury with coexisting immunocompromised status appears to predispose adults to this rare manifestation of Salmonella infection. We report a case of Salmonella brain abscess in a patient w...

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Bibliographic Details
Published in:Journal of neurovirology 2010-02, Vol.16 (1), p.83-92
Main Authors: Soni, Chetan R, Kumar, Gyanendra, Bollu, Pradeep C, Sahota, Pradeep, Litofsky, N. Scott
Format: Article
Language:English
Subjects:
Abscess - diagnostic imaging
Abscess - microbiology
Abscess - pathology
Anti-Infective Agents - administration & dosage
Azathioprine - administration & dosage
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Brain - diagnostic imaging
Brain - microbiology
Brain - pathology
Case Report
Ciprofloxacin - administration & dosage
Drug Administration Schedule
Female
Headache - etiology
Human viral diseases
Humans
Immunology
Immunosuppression
Immunosuppressive Agents - administration & dosage
Infectious Diseases
Medical sciences
Metronidazole - administration & dosage
Middle Aged
Myasthenia Gravis - complications
Myasthenia Gravis - drug therapy
Neurology
Neurosciences
Radiography
Salmonella - drug effects
Salmonella Infections - drug therapy
Salmonella Infections - etiology
Salmonella Infections - physiopathology
Tumors of the nervous system. Phacomatoses
Viral diseases
Viral diseases of the nervous system
Virology
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Description
Summary:Focal intracranial infections caused by Salmonella species in adults are exceedingly uncommon. Structural brain injury with coexisting immunocompromised status appears to predispose adults to this rare manifestation of Salmonella infection. We report a case of Salmonella brain abscess in a patient with myasthenia gravis on chronic azathioprine therapy without any prior structural brain lesion. We reviewed world literature and discuss their analysis of Salmonella brain abscess in adult population in the postantibiotic era.
ISSN:1355-0284
1538-2443
DOI:10.3109/13550280903493906