Associations of polymorphisms in adiponectin and leptin genes with men's longevity

Adipokines are important for regulation body metabolism and immune response. Many studies have shown that variants in adipokines genes play a role in age-associated diseases. In this study, we investigated the contribution of rs266729 (−11377G/C), rs2241766 (+45T/G), and rs1501299 (+276 G/T) SNPs of...

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Bibliographic Details
Published in:The aging male 2010-09, Vol.13 (3), p.188-193
Main Authors: Khabour, Omar F., Mesmar, Fahmi S., Alatoum, Mohammad A., Gharaibeh, Mohammad Y., Alzoubi, Karem H.
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - genetics
Adult
Aged, 80 and over
Female
Gene Frequency
Genes
Genetic Association Studies - statistics & numerical data
Genotype & phenotype
Humans
Jordan
Jordan - epidemiology
leptin
Leptin - genetics
Life expectancy
longevity
Longevity - genetics
Male
Men
Metabolism
Middle Aged
Polymorphism
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Proteins
Sex Factors
SNP
Young Adult
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Summary:Adipokines are important for regulation body metabolism and immune response. Many studies have shown that variants in adipokines genes play a role in age-associated diseases. In this study, we investigated the contribution of rs266729 (−11377G/C), rs2241766 (+45T/G), and rs1501299 (+276 G/T) SNPs of adiponectin gene (ADIPQO) and rs7799039 (−2548C/A) SNP of leptin (LEP) gene to human longevity phenotype in Jordanian population. Polymorphisms were genotyped in 110 randomly selected elderly subjects (>85 years old) with mean age of 90.2 years, and 120 young control subjects (range from 20 to 50 years) with mean age of 32.0 years. No significant differences were detected in the genotype and allele frequencies of examined gene variants between the two groups (p > 0.05). However, when gender was considered, genotypes and alleles frequencies of rs1501299 SNP in ADIPOQ gene and rs7799039 in LEP gene were significantly associated with longevity in men (p  0.05). Thus, ADIPOQ and LEP genes polymorphisms might play a gender-specific role in the pathway to men's longevity.
ISSN:1368-5538
1473-0790
DOI:10.3109/13685531003657800