A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM

Objective: Antibiotic administration is a standard practice in preterm premature rupture of membranes (PROM). Specific anti-microbial agents often include ampicillin and/or erythromycin. Anaerobes and genital mycoplasmas are frequently involved in preterm PROM, but are not adequately covered by anti...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2016-03, Vol.29 (5), p.707-720
Main Authors: Lee, JoonHo, Romero, Roberto, Kim, Sun Min, Chaemsaithong, Piya, Park, Chan-Wook, Park, Joong Shin, Jun, Jong Kwan, Yoon, Bo Hyun
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - administration & dosage
Ceftriaxone
Ceftriaxone - administration & dosage
cerebral palsy
Chorioamnionitis - drug therapy
Chorioamnionitis - epidemiology
clarithromycin
Clarithromycin - administration & dosage
Drug Therapy, Combination
Female
Fetal Membranes, Premature Rupture - drug therapy
Fetal Membranes, Premature Rupture - epidemiology
Humans
Infant, Newborn
intra-amniotic infection
intra-amniotic inflammation
intra-ventricular hemorrhage
metronidazole
Metronidazole - administration & dosage
Obstetric Labor, Premature - drug therapy
Obstetric Labor, Premature - epidemiology
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Pregnancy Complications, Infectious - epidemiology
Pregnancy Outcome - epidemiology
preterm birth
Retrospective Studies
Time Factors
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Summary:Objective: Antibiotic administration is a standard practice in preterm premature rupture of membranes (PROM). Specific anti-microbial agents often include ampicillin and/or erythromycin. Anaerobes and genital mycoplasmas are frequently involved in preterm PROM, but are not adequately covered by antibiotics routinely used in clinical practice. Our objective was to compare outcomes of PROM treated with standard antibiotic administration versus a new combination more effective against these bacteria. Study design: A retrospective study compared perinatal outcomes in 314 patients with PROM 23 ng/mL). Results: (1) Patients treated with regimen 2 had a longer median antibiotic-to-delivery interval than those with regimen 1 [median (interquartile range) 23 d (10-51 d) versus 12 d (5-52 d), p 
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2015.1020293