Ischemia-modified albumin as an oxidative stress biomarker in early pregnancy loss

Background/aims: This study aimed to determine the association between early pregnancy loss and serum ischemia-modified albumin (IMA) concentrations. Methods: Serum samples of 180 women that included healthy pregnant women, women admitted for termination of pregnancy due to the absence of fetal card...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2016-06, Vol.29 (11), p.1754-1757
Main Authors: Cengiz, Huseyin, Dagdeviren, Hediye, Kanawati, Ammar, Suzen Çaypinar, Sema, Yesil, Ali, Ekin, Murat, Yasar, Levent
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Case-Control Studies
Defective placentation
early pregnancy loss
Female
Fetal Death
Humans
ischemia-modified albumin
Oxidative Stress
Pregnancy
ROC Curve
Serum Albumin
Serum Albumin, Human
Young Adult
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Summary:Background/aims: This study aimed to determine the association between early pregnancy loss and serum ischemia-modified albumin (IMA) concentrations. Methods: Serum samples of 180 women that included healthy pregnant women, women admitted for termination of pregnancy due to the absence of fetal cardiac activity or absence of fetal pole on ultrasonographic examination, and healthy non-pregnant women attending for gynecological examination. Each group included 60 patients. Serum concentrations of IMA were compared among the groups, and the correlations with patients' age, gravidity, BMI, gestational age and total serum albumin concentrations were calculated. Results: When the groups were compared with respect to IMA concentrations, the group with early pregnancy loss was found to have significantly higher IMA concentrations (p 163 ng/mL had a sensitivity of 75%, specificity of 55% to discriminate between healthy pregnant patients and patients with early pregnancy loss in first trimester. Conclusion: Our findings support the theory that possible oxidative stress, a more hypoxic environment and defective placentation lead to increased serum IMA concentrations. These findings may help to shed light on the complicated pathogenesis of early pregnancy loss.
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2015.1061494