The effects of preconception examinations on neural tube defects and the primary preventive measures: case-control study

Background: Preventive measures for neural tube defects (NTDs) have been recommended for many years in China, but the compliance with these measures is unsatisfactory. This study aims to analyze the effects of preconception examinations on NTDs and its primary preventive measures. Methods: A 1:1 hos...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2016-09, Vol.29 (17), p.2773-2779
Main Authors: Gong, Rui, Wang, Zhi-Ping, Wang, Meng, Gao, Li-Jie, Lu, Qing-Bin, Zhao, Zhong-Tang
Format: Article
Language:English
Subjects:
Adolescent
Adult
Case-Control Studies
Dietary Supplements
Female
Folic Acid - administration & dosage
Hematinics - administration & dosage
Humans
neural tube defects
Neural Tube Defects - prevention & control
Preconception Care
Preconception examinations
Pregnancy
primary prevention
Young Adult
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Summary:Background: Preventive measures for neural tube defects (NTDs) have been recommended for many years in China, but the compliance with these measures is unsatisfactory. This study aims to analyze the effects of preconception examinations on NTDs and its primary preventive measures. Methods: A 1:1 hospital-based case-control study was conducted. Four hundred and fifty-nine women who delivered or gestate infants/fetuses with NTDs from January 2006 to December 2008 were randomly selected and matched with women who delivered babies without obvious birth defects as controls in Shandong and Shanxi province. Multivariate conditional logistic regression was adopted. Results: Significant associations were shown between preconception examinations (OR = 0.461), health education (OR = 0.336), periconceptional folic acid supplement (OR = 0.295), periconceptional rational diet adjustment (OR = 0.278) and NTDs. In the case group, the rates of periconceptional folic acid supplement and health education conduction by women who had preconception examinations were significantly higher than that of those who had not, OR being 3.04 and 4.55, respectively (p 
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2015.1103726