QUANTITATIVE ANALYSIS OF AMLODIPINE BESYLATE AND VALSARTAN IN TABLET DOSAGE FORM BY ABSORPTION FACTOR SPECTROPHOTOMETRY METHOD

This study aimed to develop a spectrophotometry method by absorption factor using methanol solvent to get the levels of amlodipine besylate and valsartan in the tablet. This method is very simple, to find the levels of valsartan was substracted the absorption of amlodipine besylate at 247.2 nm using...

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Bibliographic Details
Published in:Rasāyan journal of chemistry 2022, Vol.15 (2), p.1386-1389
Main Authors: Sinaga, S. M., Pertiwi, N.N., Muchlisyam
Format: Article
Language:English
Online Access:Get full text
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Summary:This study aimed to develop a spectrophotometry method by absorption factor using methanol solvent to get the levels of amlodipine besylate and valsartan in the tablet. This method is very simple, to find the levels of valsartan was substracted the absorption of amlodipine besylate at 247.2 nm using an experimentally calculated absorption factor. The maximum wavelengths of amlodipine besylate and valsartan were obtained 358.0 nm and 247.2 nm, respectively. The average % recoveries were obtained in 100.16% and 99.71% for amlodipine besylate and valsartan to 5/80 mg tablet dosage form and 100.29% and 99.64% for amlodipine besylate and valsartan, respectively to 10/160 mg tablet dosage form. This method is successfully applied to determine amlodipine besylate and valsartan in tablet preparation without interference from excipients as shown in recovery studies and fulfill the validation requirements.
ISSN:0974-1496
0974-1496
DOI:10.31788/RJC.2022.1526611