The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients

Among trauma patients who survive to reach hospital, exsanguination is a common cause of death. A widely practicable treatment that reduces blood loss after trauma could prevent thousands of premature deaths each year. The CRASH-2 trial aimed to determine the effect of the early administration of tr...

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Bibliographic Details
Published in:	Health technology assessment (Winchester, England) England), 2013-03, Vol.17 (10), p.1-79
Main Authors:	Roberts, I, Shakur, H, Coats, T, Hunt, B, Balogun, E, Barnetson, L, Cook, L, Kawahara, T, Perel, P, Prieto-Merino, D, Ramos, M, Cairns, J, Guerriero, C
Format:	Article
Language:	English
Subjects:	Adult Antifibrinolytic Agents - therapeutic use bleeding trauma patients Blood Transfusion Confidence Intervals cost-effectiveness Craniocerebral Trauma - mortality crash-2 Female Hemorrhage - mortality Hemorrhage - prevention & control Hospital Mortality Humans Internationality Male Middle Aged Multiple Organ Failure - mortality Multiple Organ Failure - prevention & control Outcome Assessment, Health Care - statistics & numerical data randomised controlled trial Thrombosis - mortality Thrombosis - prevention & control tranexamic acid Tranexamic Acid - therapeutic use Wounds, Nonpenetrating - mortality Wounds, Penetrating - mortality Young Adult
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