SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course

I In the last decade, the B-cell receptor has emerged as a pivotal stimulus in the pathogenesis of chronic lymphocytic leukemia, and a very feasible therapeutic target in this disease. B-cell receptor responsiveness in chronic lymphocytic leukemia cells is heterogeneous among patients and correlates...

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Bibliographic Details
Published in:Haematologica (Roma) 2016-12, Vol.101 (12), p.1553-1562
Main Authors: Dezorella, N., Katz, B.-Z., Shapiro, M., Polliack, A., Perry, C., Herishanu, Y.
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Disease Progression
Gene Expression Regulation, Leukemic
Gene Knockdown Techniques
Humans
Immunoglobulin Heavy Chains - genetics
Kaplan-Meier Estimate
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - metabolism
Leukemia, Lymphocytic, Chronic, B-Cell - mortality
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Phosphoproteins - genetics
Phosphoproteins - metabolism
Phosphorylation
Prognosis
Protein Binding
Receptors, Antigen, B-Cell - metabolism
Signal Transduction
Syk Kinase - metabolism
ZAP-70 Protein-Tyrosine Kinase - genetics
ZAP-70 Protein-Tyrosine Kinase - metabolism
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