Golgi defect as a major contributor to lysosomal dysfunction

The Golgi apparatus plays a crucial role in lysosome biogenesis and the delivery of lysosomal enzymes, essential for maintaining cellular homeostasis and ensuring cell survival. Deficiencies in Golgi structure and function can profoundly impact lysosomal homeostasis, leading to various lysosomal sto...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2024-04, Vol.12, p.1386149
Main Authors: Akaaboune, Sarah R., Wang, Yanzhuang
Format: Article
Language:English
Subjects:
Cell and Developmental Biology
Cell cycle
Cell survival
Endoplasmic reticulum
Enzymes
Eukaryotes
Golgi
Golgi cells
GRASP55
GRASP65
HexA
Homeostasis
Lipids
Lysosomal enzymes
Lysosomal storage diseases
lysosome
Lysosomes
Molecular weight
Mutation
Neurodegenerative diseases
Phosphorylation
Physiology
Proteins
Structure-function relationships
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