Synthesis, Selective Cytotoxic Activity against Human Breast Cancer MCF7 Cell Line and Molecular Docking of Some Chalcone-Dihydropyrimidone Hybrids

Designed Chalcone-Dihydropyrimidinone hybrid compounds were synthesized expeditiously. The hybridization was performed through the Copper-catalyzed Alkyne-Azide Cycloaddition (CuAAC) from the propargyloxy chalcones and azido-dihydropyrimidinones. The hybrid products were prepared in five steps with...

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Bibliographic Details
Published in:Drugs and drug candidates 2022-12, Vol.1 (1), p.3-21
Main Authors: Mass, Eduardo B., de Lima, Carolina A., D’Oca, Marcelo G. M., Sciani, Juliana M., Longato, Giovanna B., Russowsky, Dennis
Format: Article
Language:English
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Summary:Designed Chalcone-Dihydropyrimidinone hybrid compounds were synthesized expeditiously. The hybridization was performed through the Copper-catalyzed Alkyne-Azide Cycloaddition (CuAAC) from the propargyloxy chalcones and azido-dihydropyrimidinones. The hybrid products were prepared in five steps with a 30–48% overall yield. Most of the compounds showed selective cytotoxicity and lower IC50 values (
ISSN:2813-2998
2813-2998
DOI:10.3390/ddc1010002