Fucosterol, a Phytosterol of Marine Algae, Attenuates Immobilization-Induced Skeletal Muscle Atrophy in C57BL/6J Mice

The objective of this study was to examine whether fucosterol, a phytosterol of marine algae, could ameliorate skeletal muscle atrophy in tumor necrosis factor-alpha (TNF-α)-treated C2C12 myotubes and in immobilization-induced C57BL/6J mice. Male C57BL6J mice were immobilized for 1 week to induce sk...

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Published in:	Marine drugs 2024-12, Vol.22 (12), p.557
Main Authors:	Hwang, Jieun, Kim, Mi-Bo, Lee, Sanggil, Hwang, Jae-Kwan
Format:	Article
Language:	English
Subjects:	1-Phosphatidylinositol 3-kinase AKT protein Akt/mTOR/FoxO3α pathway Algae Animals Atrophy Biodegradation Cell Line Cytokines Diabetes Exercise Forkhead Box Protein O3 - metabolism Forkhead protein Fucosterol Gene expression Immobilization Inflammation Kinases Male Mice Mice, Inbred C57BL Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - metabolism Muscle function Muscle Proteins - metabolism Muscle strength Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscles Muscular Atrophy - drug therapy Musculoskeletal system Myotubes Necrosis Oral administration Phosphatidylinositol Phosphorylation Phosphorylation - drug effects Physiology Phytosterols Phytosterols - pharmacology Protein binding Protein biosynthesis Protein expression Protein synthesis Proteins Proteolysis Proto-Oncogene Proteins c-akt - metabolism Quality of life Rapamycin Ribosomal protein S6 Ribosomal protein S6 kinase Signal transduction Signal Transduction - drug effects Skeletal muscle skeletal muscle atrophy Stigmasterol - analogs & derivatives Stigmasterol - pharmacology TOR protein TOR Serine-Threonine Kinases - metabolism Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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