IFITM3 Clusters on Virus Containing Endosomes and Lysosomes Early in the Influenza A Infection of Human Airway Epithelial Cells

Interferon-induced transmembrane proteins (IFITMs) have been shown to strongly affect influenza A virus (IAV) infectivity in tissue culture. Moreover, polymorphisms in IFITM3 have been associated with the severity of the disease in humans. IFITM3 appears to act early in the infection, but its mechan...

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Bibliographic Details
Published in:Viruses 2019-06, Vol.11 (6), p.548
Main Authors: Kummer, Susann, Avinoam, Ori, Kräusslich, Hans-Georg
Format: Article
Language:English
Subjects:
Antibodies
Cell culture
cluster analysis
Computer applications
Endosomes
endosomes/lysosomes
Epithelial cells
Genomes
human cell lines
humans
IFITM3
Infections
Infectivity
Influenza
Influenza A
Influenza A virus
Interferon
Localization
lungs
Lysosomes
mechanism of action
Membrane proteins
Microscopy
pathogenicity
phenotype
Phenotypes
Plasmids
Polymorphism
Protein turnover
Proteins
Respiratory tract
super-resolution microscopy
Tissue culture
transmembrane proteins
Vesicles
viral-host interaction
Viruses
West Nile virus
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