The Conserved YPX3L Motif in the BK Polyomavirus VP1 Protein Is Important for Viral Particle Assembly but Not for Its Secretion into Extracellular Vesicles

The BK polyomavirus (BKPyV) is a small DNA non-enveloped virus whose infection is asymptomatic in most of the world’s adult population. However, in cases of immunosuppression, the reactivation of the virus can cause various complications, and in particular, nephropathies in kidney transplant recipie...

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Bibliographic Details
Published in:	Viruses 2024-07, Vol.16 (7), p.1124
Main Authors:	Bentz, Marine, Collet, Louison, Morel, Virginie, Descamps, Véronique, Blanchard, Emmanuelle, Lambert, Caroline, Demey, Baptiste, Brochot, Etienne, Helle, Francois
Format:	Article
Language:	English
Subjects:	adults Antibodies BKPyV bone marrow transplant Bone marrow transplantation capsid assembly cystitis DNA DNA viruses domain ESCRT Extracellular vesicles Genotype & phenotype Hemorrhagic cystitis Human polyomavirus 1 Immunosuppression Infections kidney transplant Kidney transplantation late domain Life Sciences Lysis Machinery Microbiology and Parasitology Mutagenesis Mutation Plasmids Point mutation Protein transport Proteins Recruitment secretion Structural proteins Transplants & implants virion Virions Virology Viruses VP1 protein
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