Antifungal Therapy of Burn Patients: Susceptibility of Fungal Strains Clinically Isolated from Burn Patients, and the Dose of Fluconazole

The aim of the present study was to evaluate the efficacy of fluconazole when administered to burn patients according to the protocol. Between October 1997 and December 1998, we investigated the susceptibility of 59 fungal strains clinically isolated from 18 severely burned patients, the patients�...

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Bibliographic Details
Published in:Nihon Kyukyu Igakukai Zasshi 2000/08/15, Vol.11(8), pp.369-378
Main Author: Anze, Masanori
Format: Article
Language:English
Subjects:
burn
deep-seated fungal infection
fluconazole
serum concentration
susceptibility test
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Summary:The aim of the present study was to evaluate the efficacy of fluconazole when administered to burn patients according to the protocol. Between October 1997 and December 1998, we investigated the susceptibility of 59 fungal strains clinically isolated from 18 severely burned patients, the patients' serum concentration of fluconazole after treatment, and the serum β-D glucan titers of 6 deep-seated fungal-infected patients. In a susceptibility test of 3 antifungal agents: fluconazole, amphotericine-B, and flucytosine, fluconazole exhibited a broad distribution of MICs (0.25∼8μg/ml), and 23.7% of the C. albicans strains had a high MIC (8μg/ml). No such high-MIC strains were detected in wards other than the burn unit. In a comparison between the C. albicans group (n=38) and non-albicans group (C. tropicalis 18, yeast-like fungi 3), the MIC80 was 5.06 vs 37μg/ml for FLCZ, 0.80 vs 0.488μg/ml for AMPH-B and
ISSN:0915-924X
1883-3772
DOI:10.3893/jjaam.11.369