Regulation of Cystic Fibrosis Transmembrane Conductance Regulator by MicroRNA-145, -223, and -494 Is Altered in ΔF508 Cystic Fibrosis Airway Epithelium

Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) is altered in individuals with the ΔF508 CFTR mutation. We previously reported differential expression of microRNA (miRNA) in CF airway epithelium; however, the role of miRNA in regulation of CFTR expression here remains un...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2013-04, Vol.190 (7), p.3354-3362
Main Authors: Oglesby, Irene K, Chotirmall, Sanjay H, McElvaney, Noel G, Greene, Catherine M
Format: Article
Language:English
Subjects:
3' Untranslated Regions
Adult
Base Sequence
Cell Line
Chlorides - metabolism
Cystic Fibrosis - genetics
Cystic Fibrosis - metabolism
Cystic Fibrosis - microbiology
Cystic Fibrosis Transmembrane Conductance Regulator - genetics
Cystic Fibrosis Transmembrane Conductance Regulator - metabolism
Female
Gene Expression
Gene Expression Profiling
Gene Expression Regulation
Gene Knockdown Techniques
Genotype
Humans
Intracellular Space - metabolism
Lung - metabolism
Lung - microbiology
Male
MicroRNAs - chemistry
MicroRNAs - genetics
MicroRNAs - metabolism
Pseudomonas
Pseudomonas aeruginosa
Pseudomonas aeruginosa - metabolism
Respiratory Mucosa - metabolism
Respiratory Mucosa - microbiology
Respiratory Mucosa - pathology
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