Cutting Edge: Human γδ T Cells Are Activated by Intermediates of the 2- C -methyl- d -erythritol 4-phosphate Pathway of Isoprenoid Biosynthesis

Activation of Vγ9/Vδ2 T cells by small nonprotein Ags is frequently observed after infection with various viruses, bacteria, and eukaryotic parasites. We suggested earlier that compounds synthesized by the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway of isopentenyl pyrophosphate synthesis are r...

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Published in:The Journal of immunology (1950) 2001-03, Vol.166 (6), p.3655-3658
Main Authors: Altincicek, Boran, Moll, Jens, Campos, Narciso, Foerster, Gesine, Beck, Ewald, Hoeffler, Jean-François, Grosdemange-Billiard, Catherine, Rodríguez-Concepción, Manuel, Rohmer, Michel, Boronat, Albert, Eberl, Matthias, Jomaa, Hassan
Format: Article
Language:English
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Summary:Activation of Vγ9/Vδ2 T cells by small nonprotein Ags is frequently observed after infection with various viruses, bacteria, and eukaryotic parasites. We suggested earlier that compounds synthesized by the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway of isopentenyl pyrophosphate synthesis are responsible for the Vγ9/Vδ2 T cell reactivity of many pathogens. Using genetically engineered Escherichia coli knockout strains, we now demonstrate that the ability of E. coli extracts to stimulate γδ T cell proliferation is abrogated when genes coding for essential enzymes of the MEP pathway, dxr or gcpE, are disrupted or deleted from the bacterial genome.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.166.6.3655