Serum S100B protein as a prognostic biomarker for neurological outcome after in-hospital cardiac arrest in children

• Published in: Tanta Medical Journal 2018-04, Vol.46 (2), p.133-138
• Main Authors: Abd Elsalam, Ahmed, AboElezz, Ahmed, El-Bendary, Amal, Zoair, Amr
• Format: Article
• Language: English
• ISSN: 1110-1415; 2314-8624
• DOI: 10.4103/tmj.tmj_37_17

Background Survivors of cardiac arrest often require lengthy intensive care admission, rehabilitation, and ongoing treatment of chronic complications as a result of poor function outcomes. S100B protein has emerged as a candidate peripheral biomarker of blood-brain barrier permeability and central nervous system injury. Aim This study aimed to evaluate the serum levels of S100B protein as a prognostic biomarker for predicting neurological outcome after in-hospital cardiac arrest and cardiopulmonary resuscitation (CPR) in children. Patients and methods Thirty infants and children underwent CPR after in-hospital cardiac arrest; blood samples for the evaluation of S100B were drawn after 1 and 24 h after initiation of CPR. Neurological assessment for survivors was done 6 months after cardiac arrest using the cerebral performance category (CPC) score, which was used also immediately following CPR for all patients (including those who died 24 h after CPR). Fifteen healthy children were enrolled as a control group. Results There was highly significant increase of serum S100B protein in postarrest patients at 1 and 24 h as compared with the control group (P