Viruses and arrested autophagosome development

Autophagy is acknowledged as an important cellular defense mechanism against intracellular pathogens.  As with other innate immune responses, pathogens have adapted to evade autophagy and in some cases, subvert the pathway to promote their own replication. Poliovirus, a prototypical small positive-s...

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Bibliographic Details
Published in:Autophagy 2009-08, Vol.5 (6), p.870-871
Main Authors: Taylor, Matthew P., Jackson, William T.
Format: Article
Language:English
Subjects:
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Green Fluorescent Proteins - metabolism
Landes
Microtubule-Associated Proteins - metabolism
Models, Biological
Mutation - genetics
Organogenesis
Phagosomes - virology
Poliovirus - physiology
Proteins
Viral Proteins - metabolism
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Summary:Autophagy is acknowledged as an important cellular defense mechanism against intracellular pathogens.  As with other innate immune responses, pathogens have adapted to evade autophagy and in some cases, subvert the pathway to promote their own replication. Poliovirus, a prototypical small positive-strand RNA virus that replicates and assembles in the cytoplasm of the host cell, utilizes membranes derived from the autophagic pathway to aid viral replication and egress from the cell. Recently we made the surprising discovery that GFP-LC3-staining vesicles are physically immobilized during poliovirus infection. Here we discuss our model for the mechanism of vesicle immobilization and the predictions it makes for pathogens that subvert the autophagic pathway to their own ends.
ISSN:1554-8627
1554-8635
DOI:10.4161/auto.9046