Sirt1: Def-eating senescence?

Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively investigated in the last few years as an avenue to understand the connection linking nutrients and energy metabolism with aging and related diseases. From this research effort the picture has emerged of an...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2012-11, Vol.11 (22), p.4135-4146
Main Authors: Fusco, Salvatore, Maulucci, Giuseppe, Pani, Giovambattista
Format: Article
Language:English
Subjects:
Aging
Animals
Binding
Biology
Bioscience
Calcium
calorie restriction
Cancer
Cell
Cycle
Cyclic AMP Response Element-Binding Protein - metabolism
DNA Damage
Histones - metabolism
Humans
Landes
metabolic disease
nutrient signaling
Organogenesis
Proteins
Review
Sirt1
Sirtuin 1 - genetics
Sirtuin 1 - metabolism
Transcription Factors - metabolism
Transcription, Genetic
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