Partitioning Viral Genomes in Mitosis: Same Idea, Different Targets

Papillomavirus infections are long-lived and persistent. The circular DNA of the viral genome is maintained in dividing epithelial cells as an extrachromosomal element. The E2 protein of the virus binds to the viral genome and tethers it to mitotic chromosomes to ensure that the genome is retained a...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2006-07, Vol.5 (14), p.1499-1502
Main Authors: McBride, Alison A., Oliveira, Jaquelline G., McPhillips, Maria G.
Format: Article
Language:English
Subjects:
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cell Division
Cycle
DNA-Binding Proteins - metabolism
DNA-Binding Proteins - physiology
Genome, Viral - physiology
Humans
Landes
Mitosis - genetics
Organogenesis
Papillomaviridae - genetics
Papillomaviridae - pathogenicity
Papillomavirus Infections - pathology
Proteins
Viral Envelope Proteins - metabolism
Viral Proteins - metabolism
Viral Proteins - physiology
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Summary:Papillomavirus infections are long-lived and persistent. The circular DNA of the viral genome is maintained in dividing epithelial cells as an extrachromosomal element. The E2 protein of the virus binds to the viral genome and tethers it to mitotic chromosomes to ensure that the genome is retained and faithfully partitioned in dividing cells. This mechanism has been best studied for bovine papillomavirus type 1. Recent evidence indicates that while this is a common strategy among papillomaviruses, different viruses have evolved different chromosomal targets.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.5.14.3094