Damaged-self recognition as a general strategy for injury detection

Plants perceive endogenous molecules or their fragments as signals of danger when these appear at increased concentrations in the extracellular space, and they respond with increased endogenous levels of jasmonic acid. The wound hormone jasmonic acid represents a central player in the induced resist...

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Bibliographic Details
Published in:Plant signaling & behavior 2012-05, Vol.7 (5), p.576-580
Main Author: Heil, Martin
Format: Article
Language:English
Subjects:
alarmins
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Cyclopentanes - metabolism
damage-associated molecular patterns
damaged-self recognition
DAMPs
Disease Resistance - physiology
Extracellular Matrix
extracellular space
herbivores
humans
immune system
Immunologic Factors
induced resistance
jasmonic acid
Landes
octadecanoid signalling
Organogenesis
Oxylipins - metabolism
pathogens
Plant Diseases
Plant Growth Regulators - physiology
Plant Immunity - physiology
Proteins
Review
Signal Transduction - physiology
sterile inflammation
Stress, Physiological
wound response
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Summary:Plants perceive endogenous molecules or their fragments as signals of danger when these appear at increased concentrations in the extracellular space, and they respond with increased endogenous levels of jasmonic acid. The wound hormone jasmonic acid represents a central player in the induced resistance of plants to herbivore feeding and infection by necrotrophic pathogens. This 'damaged self recognition' mechanism of plants exhibits astonishing similarities to the perception of 'damage-associated molecular patterns' (DAMPs) by the human immune system: endogenous cell constituents, or their fragments, that can be released into the extracellular milieu during states of cellular stress or damage function as 'stress signals' and trigger inflammatory and other immunity-related responses. Multicellular organisms use endogenous molecules as danger signals to mount adequate healing and resistance-related responses without depending on exogenous signals and to place exogenous, enemy-derived molecular signals into the adequate functional context.
ISSN:1559-2316
1559-2324
1559-2324
DOI:10.4161/psb.19921