Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility

The inwardly rectifying K+ channel Kir4.1 is broadly expressed by CNS glia and deficits in Kir4.1 lead to seizures and myelin vacuolization. However, the role of oligodendrocyte Kir4.1 channels in controlling myelination and K+ clearance in white matter has not been defined. Here, we show that selec...

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Bibliographic Details
Published in:	eLife 2018-03, Vol.7
Main Authors:	Larson, Valerie A, Mironova, Yevgeniya, Vanderpool, Kimberly G, Waisman, Ari, Rash, John E, Agarwal, Amit, Bergles, Dwight E
Format:	Article
Language:	English
Subjects:	Animals Ataxia Axons Central nervous system Confidence intervals epilepsy Gene Deletion Gene expression Glial stem cells Homeostasis Kir4.1 Mice Mice, Knockout Mice, Transgenic myelin Myelin Sheath - metabolism Myelination Neuroscience oligodendrocyte Oligodendrocytes Oligodendroglia - enzymology Oligodendroglia - metabolism Optic nerve potassium Potassium - metabolism Potassium channels Potassium channels (inwardly-rectifying) Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Rodents seizure Seizures Seizures - physiopathology Software Substantia alba White Matter - metabolism
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