Characterization data on the topical carrier DDC642

This article contains original data, figures and methods used in the characterization of the liposomal carrier ‘DDC642’ for topical applications, described in “An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: proof-of-concept in the treatment of psoriasis” (Desmet...

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Bibliographic Details
Published in:Data in brief 2016-06, Vol.7, p.1204-1210
Main Authors: Desmet, Eline, Bracke, Stefanie, Forier, Katrien, Taevernier, Lien, Stuart, Marc C.A., De Spiegeleer, Bart, Raemdonck, Koen, Van Gele, Mireille, Lambert, Jo
Format: Article
Language:English
Subjects:
Data
Gene therapy
Lipid-based nanoparticle
Liposome
RNA interference
Topical drug delivery
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Summary:This article contains original data, figures and methods used in the characterization of the liposomal carrier ‘DDC642’ for topical applications, described in “An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: proof-of-concept in the treatment of psoriasis” (Desmet et al., 2016) [1]. Several elastic liposomal formulations have been evaluated for their ability to encapsulate and deliver RNA interference (RNAi) molecules to cultured primary skin cells. The efficiency and effectiveness of these liposomes were compared to that of our previously characterized liposomes, the ‘SECosomes’ (SEC) (Geusens et al., 2010) [2]. After selection of a potential superior carrier, based on encapsulation and transfection efficiency data (Desmet et al., 2016) [1], the selected DDC642 liposomes were characterized more in-depth. Herein, a detailed characterization of the DDC642 liposome and RNAi-loaded lipoplexes is given, including the matching protocols.
ISSN:2352-3409
2352-3409
DOI:10.1016/j.dib.2016.03.091