Albuminuria in patients with chronic obstructive pulmonary disease: a cross-sectional study in an African patient cohort

Cardiovascular disease (CVD) is remarkably frequent in patients with chronic obstructive pulmonary disease (COPD). Albuminuria is a marker of vascular endothelial dysfunction and predictor of CVD events. Albuminuria is prevalent in patients with COPD as it has been shown in Caucasian and Oriental po...

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Bibliographic Details
Published in:BMC pulmonary medicine 2018-07, Vol.18 (1), p.125-125, Article 125
Main Authors: Shayo, Festo K, Lutale, Janet
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Albuminuria
Albuminuria - diagnosis
Albuminuria - epidemiology
Biomarkers - urine
Biomass energy
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - complications
Chronic obstructive lung disease
Chronic obstructive pulmonary disease
Cohort Studies
Creatinine - urine
Cross-Sectional Studies
Diagnosis
Female
Health aspects
Health risk assessment
Hospitals
Humans
Logistic Models
Lung diseases
Male
Middle Aged
Mortality
Obstructive lung disease
Outdoor air quality
Patient outcomes
Patients
Population
Pulmonary Disease, Chronic Obstructive - complications
Pulmonary Disease, Chronic Obstructive - urine
Pulmonology
Respiratory Function Tests
Risk factors
Severity of Illness Index
Spirometry
Studies
Systematic review
Tanzania
Urine
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Description
Summary:Cardiovascular disease (CVD) is remarkably frequent in patients with chronic obstructive pulmonary disease (COPD). Albuminuria is a marker of vascular endothelial dysfunction and predictor of CVD events. Albuminuria is prevalent in patients with COPD as it has been shown in Caucasian and Oriental populations with COPD. The objective of this study was to determine the prevalence of Albuminuria and COPD severity correlates among black patients with chronic obstructive pulmonary disease in order to see whether a similar trend of albuminuria is also prevalent in this population. A total of 104 COPD patients were enrolled in the study. Lung functions were assessed by means of the Easy One™ spirometer. Albuminuria defined by urine albumin to creatinine ratio (ACR) was tested using CYBOW 12MAC microalbumin strips in a random spot urine collection. SPSS version 20 was used for data analysis. In the studied population, 25/104 (24%) patients had albuminuria and 16/104 (15.4%) patients had CVD. Abnormal urine albumin (Albuminuria and Proteinuria) was present in all patients with CVD. In the subset of 46 COPD patients assessed for severity, 60.9% (95%CIs 46.1-73.9) had moderate COPD and 30.4% (95% CIs, 17.9-49.0) severe COPD. Albuminuria was moderately significantly associated with COPD severity, p = 0.049; (0.049 
ISSN:1471-2466
1471-2466
DOI:10.1186/s12890-018-0694-5