Grip-Strength-Lean-Mass Index (GSLMI) as a valuable tool for sarcopenia diagnosis and survival prognosis in cancer patients: a nationwide multicenter cohort study

To identify whether the Grip-Strength-Lean-Mass Index (GSLMI) can precisely diagnose sarcopenia and predict prognosis for cancer patients in clinical settings. A nationwide multicenter cohort study. 8,831 inpatients aged 18 years and older, histologically diagnosed with cancer and receiving anti-can...

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Published in:The Journal of nutrition, health & aging health & aging, 2025-01, Vol.29 (1), p.100409, Article 100409
Main Authors: Huo, Zhenyu, Chong, Feifei, Luo, Siyu, Li, Na, Tong, Ning, Lu, Zongliang, Guo, Jing, Zhang, Ling, Lin, Xin, Zhang, Mengyuan, Zhang, Hongmei, Shi, Muli, He, Xiumei, Liu, Jie, Song, Chunhua, Shi, Hanping, Xu, Hongxia
Format: Article
Language:English
Subjects:
Cancer
Hand grip strength
Lean mass
Mortality
Sarcopenia
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Summary:To identify whether the Grip-Strength-Lean-Mass Index (GSLMI) can precisely diagnose sarcopenia and predict prognosis for cancer patients in clinical settings. A nationwide multicenter cohort study. 8,831 inpatients aged 18 years and older, histologically diagnosed with cancer and receiving anti-cancer therapy. The GSLMI is the ratio of hand grip strength (HGS) divided by lean mass (LM), calculated by the formula: GSLMI = HGS (kg) / LM (kg). Kaplan-Meier curves and Cox models were used to estimate the association between the GSLMI and survival. A total of 3,071 (48.40%) male and 3,274 (51.60%) female patients were enrolled in the study. The prevalence of GLIS-defined sarcopenia was 2,646 (41.70%). The optimal sex-specific thresholds with the best diagnostic performance to identify a low GSLMI were determined to be
ISSN:1279-7707
1760-4788
1760-4788
DOI:10.1016/j.jnha.2024.100409