Association of physical activity and sleep habits during pregnancy with autistic spectrum disorder in 3-year-old infants

• Published in: Communications medicine 2022-04, Vol.2 (1), p.35-35, Article 35
• Main Authors: Nakahara, Kazushige, Michikawa, Takehiro, Morokuma, Seiichi, Hamada, Norio, Ogawa, Masanobu, Kato, Kiyoko, Sanefuji, Masafumi, Shibata, Eiji, Tsuji, Mayumi, Shimono, Masayuki, Kawamoto, Toshihiro, Ohga, Shouichi, Kusuhara, Koichi
• Format: Article
• Language: English
• Subjects: 692/308/174; 692/308/3187; 692/699/476/1373; 692/700/478/174; Medicine; Medicine & Public Health
• ISSN: 2730-664X; 2730-664X
• DOI: 10.1038/s43856-022-00101-y

Background: We hypothesized that maternal lifestyle factors, such as physical activity and sleep habits, may be associated with autism spectrum disorder (ASD) in infants. This study aimed to investigate the association between maternal physical activity and sleep before and during pregnancy with infant ASD diagnosed by the age of 3 years. Methods: We used the data from the Japan Environment and Children’s Study between 2011 and 2014. The study included 103,060 pregnant women, among which, 69,969 women were analyzed. Participants were asked about their physical activity and sleep before and during pregnancy using questionnaires during pregnancy. Maternal physical activity was estimated using the international physical activity questionnaire. Based on the levels of physical activity before or during pregnancy, the participants were divided into five groups. Maternal sleep was analyzed based on sleep duration and bedtime. The outcome was diagnosis of ASD in 3-year-old infants. Results: In mothers with higher physical activity levels during pregnancy, the risk ratios (RR) for ASD in their 3-year-old infants were lower (RR = 0.61, 95% confidence interval (CI) = 0.42–0.90). In contrast, too short (10 h) sleep durations during pregnancy were associated with higher risk ratios for ASD than 7–8 h sleep duration (too short: RR = 1.87, 95% CI = 1.21–2.90; too long: RR = 1.56, 95% CI = 1.00–2.48). These associations were not observed before pregnancy. Conclusion: Maternal physical activity and sleep duration during pregnancy may be associated with ASD in infants. Plain language summary Children with autism spectrum disorder (ASD) have difficulties with communication and can have problematic behavior. It is unclear whether lifestyle habits before and during pregnancy influence the chances of having a child with ASD. We investigated whether maternal physical activity and particular sleep habits before and during pregnancy increased the likelihood of 3-year-old infants having ASD. Mothers completed questionnaires asking about their physical activity, sleep habits, and any diagnosis of ASD in their child. The children of mothers with high levels of physical activity during pregnancy were less likely to have ASD. The children of mothers who had slept for less than 6 h or longer than 10 h a night were more likely to have ASD. Thus, improving sleep and increasing exercise during pregnancy might reduce the risk of ASD in their children. Nakahara, Michikaw