Extraction and evaluation of 'Lepidium sativum' and flax seeds mucilage as a pharmaceutical granulation binder

• Published in: British Journal of Pharmacy 2021-09, Vol.6 (1), p.1-11
• Main Authors: Layas, Nagla Algali, Aljabri, Sumaya O., Mohamed, Aref T., Alshaafi, Aisha M., Algondi, Amna K., Alshrif, Malak M.
• Format: Article
• Language: English
• Subjects: binder; Evaluation; flax seeds; Flaxseed; granules; lepidium sativum; Matter; Mucilage; physical properties; Povidone; Properties; pvp
• ISSN: 2058-8356; 2058-8356
• DOI: 10.5920/bjpharm.851

The powders hold together by a binder to form granule. Some excipients of natural origins are currently available as an alternative over the synthetic ones in pharmaceutical formulation. The aim of this study was to isolate the mucilage from different plant seeds and compare them to evaluate the binding effects. In present study an effort was made to investigate the efficacy of mucilage obtained from Lepidium sativum and flax seeds as granules excipient. The mucilage was extracted from selected seeds by conventional method by precipitation of soaked and blended seeds in acetone. The dried mucilages were subjected to several phytochemical and physicochemical properties. Granules were formulated by wet granulation method by using extracted mucilage as a binding agent and comparison was made against the granules prepared with standard binder as PVP. The granules evaluated by various physical properties such as (bulk and tapped densities, Hausner's ratio, Carr's index, angle of repose and friability). The results showed that the granules prepared from extracted mucilage as a binder had good flow and mechanical properties, all evaluated parameters were within the permissible limits. Thus, mucilage could be used as an alternative binding agent in pharmaceutical granules.