Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort: ELSA-Brasil study

Homeostasis model assessment of insulin resistance (HOMA-IR) is a method to measure insulin resistance. HOMA-IR cut-offs for identifying metabolic syndrome might vary across populations and body mass index (BMI) levels. We aimed to investigate HOMA-insulin resistance cut-offs that best discriminate...

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Published in:Cadernos de saúde pública 2020-01, Vol.36 (8), p.e00072120-e00072120
Main Authors: Diniz, Maria de Fátima Haueisen Sander, Beleigoli, Alline Maria Rezende, Schmidt, Maria Inês, Duncan, Bruce B, Ribeiro, Antônio Luiz P, Vidigal, Pedro G, Benseñor, Isabela M, Lotufo, Paulo A, Santos, Itamar S, Griep, Rosane H, Barreto, Sandhi Maria
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Brazil - epidemiology
Cohort Studies
Homeostasis
Humans
Insulin Resistance
Longitudinal Studies
Metabolic Syndrome
Metabolic Syndrome - diagnosis
Metabolic Syndrome - epidemiology
Middle Aged
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
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Summary:Homeostasis model assessment of insulin resistance (HOMA-IR) is a method to measure insulin resistance. HOMA-IR cut-offs for identifying metabolic syndrome might vary across populations and body mass index (BMI) levels. We aimed to investigate HOMA-insulin resistance cut-offs that best discriminate individuals with insulin resistance and with metabolic syndrome for each BMI category in a large sample of adults without diabetes in the baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Among the 12,313 participants with mean age of 51.2 (SD 8.9) years, the prevalence of metabolic syndrome was 34.6%, and 60.1% had overweight or obesity. The prevalence of metabolic syndrome among normal weight, overweight and obesity categories were, respectively, 13%, 43.2% and 60.7%. The point of maximum combined sensitivity and specificity of HOMA-IR to discriminate the metabolic syndrome was 2.35 in the whole sample, with increasing values at higher BMI categories. This investigation contributes to better understanding HOMA-IR values associated with insulin resistance and metabolic syndrome in a large Brazilian adult sample, and that use of cut-off points according to ROC curve may be the better strategy. It also suggests that different values might be appropriate across BMI categories.
ISSN:0102-311X
1678-4464
1678-4464
DOI:10.1590/0102-311X00072120