Characterization of scrotal involvement in children and adolescents with IgA vasculitis

To characterize scrotal involvement in children and adolescents with IgA vasculitis. A cross-sectional retrospective study included 296 IgA vasculitis (EULAR/PRINTO/PRES criteria) patients, 150/296 (51%) were males and assessed by demographic/clinical/laboratory and treatments. Scrotal involvement w...

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Published in:Advances in rheumatology (London, England) England), 2018-11, Vol.58 (1), p.38-38, Article 38
Main Authors: Buscatti, Izabel M, Abrão, Henrique M, Kozu, Katia, Marques, Victor L S, Gomes, Roberta C, Sallum, Adriana M E, Silva, Clovis A
Format: Article
Language:English
Subjects:
Abdomen
Adolescents
Arthritis
Body mass index
Children
Diagnosis
Doppler effect
Edema
Glucocorticoid
Glucocorticoids
Hematuria
Henoch-Schönlein purpura
IgA vasculitis
Immunoglobulin A
Immunoglobulins
Intestinal obstruction
Kidneys
Pain
Pediatrics
Purpura
Ranitidine
RHEUMATOLOGY
Scrotal vasculitis
Serum levels
Teenagers
Testicular ultrasound
Ultrasonic imaging
Vasculitis
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container_title Advances in rheumatology (London, England)
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creator Buscatti, Izabel M
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Kozu, Katia
Marques, Victor L S
Gomes, Roberta C
Sallum, Adriana M E
Silva, Clovis A
description To characterize scrotal involvement in children and adolescents with IgA vasculitis. A cross-sectional retrospective study included 296 IgA vasculitis (EULAR/PRINTO/PRES criteria) patients, 150/296 (51%) were males and assessed by demographic/clinical/laboratory and treatments. Scrotal involvement was defined by the presence of scrotal edema and/or pain/tenderness in physical examination and/or testicular Doppler ultrasound abnormalities. Scrotal involvement was observed in 28/150 (19%) IgA vasculitis patients. This complication was evidenced at IgA vasculitis diagnosis in 27/28 (96%). Acute recurrent scrotal involvement was observed in 2/150 (1%) and none had chronic subtype. Further analysis of patients with scrotal involvement at first episode (n = 27) compared to those without this complication (n = 122) revealed that the median age at diagnosis [4.0 (2.0-12) vs. 6 (1.3-13) years, p = 0.249] was similar in both groups. The frequency of elevated serum IgA was significantly lower in IgA vasculitis patients with scrotal involvement versus without this manifestation (18% vs. 57%, p = 0.017), whereas glucocorticoid (93% vs. 49%, p 
doi_str_mv 10.1186/s42358-018-0039-3
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A cross-sectional retrospective study included 296 IgA vasculitis (EULAR/PRINTO/PRES criteria) patients, 150/296 (51%) were males and assessed by demographic/clinical/laboratory and treatments. Scrotal involvement was defined by the presence of scrotal edema and/or pain/tenderness in physical examination and/or testicular Doppler ultrasound abnormalities. Scrotal involvement was observed in 28/150 (19%) IgA vasculitis patients. This complication was evidenced at IgA vasculitis diagnosis in 27/28 (96%). Acute recurrent scrotal involvement was observed in 2/150 (1%) and none had chronic subtype. Further analysis of patients with scrotal involvement at first episode (n = 27) compared to those without this complication (n = 122) revealed that the median age at diagnosis [4.0 (2.0-12) vs. 6 (1.3-13) years, p = 0.249] was similar in both groups. The frequency of elevated serum IgA was significantly lower in IgA vasculitis patients with scrotal involvement versus without this manifestation (18% vs. 57%, p = 0.017), whereas glucocorticoid (93% vs. 49%, p &lt; 0.0001) and ranitidine use (63% vs. 30%, p = 0.003) were significantly higher in the former group. The scrotal involvement occurred in almost one fifth of IgA vasculitis patients and was commonly evidenced as acute subtype at diagnosis. Scrotal signs/symptoms improved after a prompt use of glucocorticoid and was associated with low frequency of elevated IgA serum levels.</description><identifier>ISSN: 2523-3106</identifier><identifier>EISSN: 2523-3106</identifier><identifier>DOI: 10.1186/s42358-018-0039-3</identifier><identifier>PMID: 30657092</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Abdomen ; Adolescents ; Arthritis ; Body mass index ; Children ; Diagnosis ; Doppler effect ; Edema ; Glucocorticoid ; Glucocorticoids ; Hematuria ; Henoch-Schönlein purpura ; IgA vasculitis ; Immunoglobulin A ; Immunoglobulins ; Intestinal obstruction ; Kidneys ; Pain ; Pediatrics ; Purpura ; Ranitidine ; RHEUMATOLOGY ; Scrotal vasculitis ; Serum levels ; Teenagers ; Testicular ultrasound ; Ultrasonic imaging ; Vasculitis</subject><ispartof>Advances in rheumatology (London, England), 2018-11, Vol.58 (1), p.38-38, Article 38</ispartof><rights>2018. 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The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-345106b28d8124fcd92958e22c3084c47ea68d00dcccfa6277758ac5454153643</citedby><cites>FETCH-LOGICAL-c516t-345106b28d8124fcd92958e22c3084c47ea68d00dcccfa6277758ac5454153643</cites><orcidid>0000-0001-9250-6508</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2547500963/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2547500963?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30657092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buscatti, Izabel M</creatorcontrib><creatorcontrib>Abrão, Henrique M</creatorcontrib><creatorcontrib>Kozu, Katia</creatorcontrib><creatorcontrib>Marques, Victor L S</creatorcontrib><creatorcontrib>Gomes, Roberta C</creatorcontrib><creatorcontrib>Sallum, Adriana M E</creatorcontrib><creatorcontrib>Silva, Clovis A</creatorcontrib><title>Characterization of scrotal involvement in children and adolescents with IgA vasculitis</title><title>Advances in rheumatology (London, England)</title><addtitle>Adv Rheumatol</addtitle><description>To characterize scrotal involvement in children and adolescents with IgA vasculitis. A cross-sectional retrospective study included 296 IgA vasculitis (EULAR/PRINTO/PRES criteria) patients, 150/296 (51%) were males and assessed by demographic/clinical/laboratory and treatments. Scrotal involvement was defined by the presence of scrotal edema and/or pain/tenderness in physical examination and/or testicular Doppler ultrasound abnormalities. Scrotal involvement was observed in 28/150 (19%) IgA vasculitis patients. This complication was evidenced at IgA vasculitis diagnosis in 27/28 (96%). Acute recurrent scrotal involvement was observed in 2/150 (1%) and none had chronic subtype. Further analysis of patients with scrotal involvement at first episode (n = 27) compared to those without this complication (n = 122) revealed that the median age at diagnosis [4.0 (2.0-12) vs. 6 (1.3-13) years, p = 0.249] was similar in both groups. 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A cross-sectional retrospective study included 296 IgA vasculitis (EULAR/PRINTO/PRES criteria) patients, 150/296 (51%) were males and assessed by demographic/clinical/laboratory and treatments. Scrotal involvement was defined by the presence of scrotal edema and/or pain/tenderness in physical examination and/or testicular Doppler ultrasound abnormalities. Scrotal involvement was observed in 28/150 (19%) IgA vasculitis patients. This complication was evidenced at IgA vasculitis diagnosis in 27/28 (96%). Acute recurrent scrotal involvement was observed in 2/150 (1%) and none had chronic subtype. Further analysis of patients with scrotal involvement at first episode (n = 27) compared to those without this complication (n = 122) revealed that the median age at diagnosis [4.0 (2.0-12) vs. 6 (1.3-13) years, p = 0.249] was similar in both groups. The frequency of elevated serum IgA was significantly lower in IgA vasculitis patients with scrotal involvement versus without this manifestation (18% vs. 57%, p = 0.017), whereas glucocorticoid (93% vs. 49%, p &lt; 0.0001) and ranitidine use (63% vs. 30%, p = 0.003) were significantly higher in the former group. The scrotal involvement occurred in almost one fifth of IgA vasculitis patients and was commonly evidenced as acute subtype at diagnosis. Scrotal signs/symptoms improved after a prompt use of glucocorticoid and was associated with low frequency of elevated IgA serum levels.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>30657092</pmid><doi>10.1186/s42358-018-0039-3</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-9250-6508</orcidid><oa>free_for_read</oa></addata></record>
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subjects Abdomen
Adolescents
Arthritis
Body mass index
Children
Diagnosis
Doppler effect
Edema
Glucocorticoid
Glucocorticoids
Hematuria
Henoch-Schönlein purpura
IgA vasculitis
Immunoglobulin A
Immunoglobulins
Intestinal obstruction
Kidneys
Pain
Pediatrics
Purpura
Ranitidine
RHEUMATOLOGY
Scrotal vasculitis
Serum levels
Teenagers
Testicular ultrasound
Ultrasonic imaging
Vasculitis
title Characterization of scrotal involvement in children and adolescents with IgA vasculitis
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