Comparative Analysis of Gut Microbiota in Centenarians and Young People: Impact of Eating Habits and Childhood Living Environment

The composition of centenarians' gut microbiota has consistently been used as a model for healthy aging studies. However, there is an incomplete understanding of how childhood living conditions and eating habits affect the development and composition of gastrointestinal microbiota in centenaria...

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Published in:Frontiers in cellular and infection microbiology 2022-03, Vol.12, p.851404-851404
Main Authors: Sepp, Epp, Smidt, Imbi, Rööp, Tiiu, Štšepetova, Jelena, Kõljalg, Siiri, Mikelsaar, Marika, Soidla, Indrek, Ainsaar, Mare, Kolk, Helgi, Vallas, Mirjam, Jaagura, Madis, Mändar, Reet
Format: Article
Language:English
Subjects:
Adolescent
Aged, 80 and over
Animals
Bacteria - genetics
Cellular and Infection Microbiology
Centenarians
childhood environment
eating habits
Feeding Behavior
Gastrointestinal Microbiome
good cognitive function
gut enterotype
Humans
Microbiota
microbiota of centenarians
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Summary:The composition of centenarians' gut microbiota has consistently been used as a model for healthy aging studies. However, there is an incomplete understanding of how childhood living conditions and eating habits affect the development and composition of gastrointestinal microbiota in centenarians with good cognitive functions. We compared the gut microbiota as well as the living and eating habits of the oldest-old group and the young people group. The richness and diversity of microbiota and the abundance of hereditary and environmental microbes were higher in people with longevity than young people. People with longevity ate more potatoes and cereal products. In their childhood, they had more exposure to farm animals and did not have sewers compared with young people. Young people's gut microbiota contained more butyrate-producing bacteria and bacteria that characterized an animal-based Western diet. These results expand our understanding of the effects of childhood environment and diet on the development and stability of the microbiota in people with longevity.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.851404