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Bacterial Pathogens and Evaluation of a Cut-Off for Defining Early and Late Neonatal Infection

Bacterial infections are an important cause of mortality and morbidity in newborns. The main risk factors include low birth weight and prematurity. The study identified the most common bacterial pathogens causing neonatal infections including their resistance to antibiotics in the Neonatal Departmen...

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Published in:	Antibiotics (Basel) 2021-03, Vol.10 (3), p.278
Main Authors:	Kucova, Pavla, Kantor, Lumir, Fiserova, Katerina, Lasak, Jakub, Röderova, Magdalena, Kolar, Milan
Format:	Article
Language:	English
Subjects:	Age Amoxicillin Ampicillin antibiotic therapy Antibiotics Bacteria Bacterial diseases Bacterial infections Birth weight Clavulanic acid Drug resistance E coli Gentamicin Gram-positive bacteria infection Infections Listeria Low-birth-weight Microorganisms Morbidity Multidrug resistant organisms Neonates newborn Pathogens Pneumonia Risk analysis Risk factors Sepsis Staphylococcus infections
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creator	Kucova, Pavla Kantor, Lumir Fiserova, Katerina Lasak, Jakub Röderova, Magdalena Kolar, Milan
description	Bacterial infections are an important cause of mortality and morbidity in newborns. The main risk factors include low birth weight and prematurity. The study identified the most common bacterial pathogens causing neonatal infections including their resistance to antibiotics in the Neonatal Department of the University Hospital Olomouc. Additionally, the cut-off for distinguishing early- from late-onset neonatal infections was assessed. The results of this study show that a cut-off value of 72 h after birth is more suitable. Only in case of early-onset infections arising within 72 h of birth, initial antibiotic therapy based on gentamicin with ampicillin or amoxicillin/clavulanic acid may be recommended. It has been established that with the 72-h cut-off, late-onset infections caused by bacteria more resistant to antibiotics may be detected more frequently, a finding that is absolutely crucial for antibiotic treatment strategy.
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subjects	Age Amoxicillin Ampicillin antibiotic therapy Antibiotics Bacteria Bacterial diseases Bacterial infections Birth weight Clavulanic acid Drug resistance E coli Gentamicin Gram-positive bacteria infection Infections Listeria Low-birth-weight Microorganisms Morbidity Multidrug resistant organisms Neonates newborn Pathogens Pneumonia Risk analysis Risk factors Sepsis Staphylococcus infections
title	Bacterial Pathogens and Evaluation of a Cut-Off for Defining Early and Late Neonatal Infection
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