Stalling the course of neurodegenerative diseases: could cyanobacteria constitute a new approach toward therapy?

Neurodegenerative diseases (NDs) are characterized by progressive and irreversible neuronal loss, accompanied by a range of pathological pathways, including aberrant protein aggregation, altered energy metabolism, excitotoxicity, inflammation, and oxidative stress. Some of the most common NDs includ...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2023-09, Vol.13 (10) (10), p.1-34
Main Authors: Ramos, Vitória, Reis, Mariana, Ferreira, Leonor, Silva, Ana Margarida, Ferraz, Ricardo, Vieira, Mónica, Vasconcelos, Vitor, Martins, Rosario
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amyotrophic lateral sclerosis
Antioxidants
Brain research
Cyanobacteria
Degeneration
Disease
Drug development
Drugs
Energy metabolism
Excitotoxicity
Fatty acids
Health aspects
Huntington's disease
Huntingtons disease
Immunomodulation
Inflammation
Metabolism
Metabolites
Microorganisms
Movement disorders
Multiple sclerosis
Natural products
Nervous system
Neurodegeneration
Neurodegenerative diseases
Neuroprotection
Oxidative metabolism
Oxidative stress
Parkinson's disease
Pathophysiology
Prokaryotes
Protein interaction
Protein turnover
Proteins
Review
Spirulina
Therapeutic targets
Tumor necrosis factor-TNF
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Summary:Neurodegenerative diseases (NDs) are characterized by progressive and irreversible neuronal loss, accompanied by a range of pathological pathways, including aberrant protein aggregation, altered energy metabolism, excitotoxicity, inflammation, and oxidative stress. Some of the most common NDs include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), and Huntington’s Disease (HD). There are currently no available cures; there are only therapeutic approaches that ameliorate the progression of symptoms, which makes the search for new drugs and therapeutic targets a constant battle. Cyanobacteria are ancient prokaryotic oxygenic phototrophs whose long evolutionary history has resulted in the production of a plethora of biomedically relevant compounds with anti-inflammatory, antioxidant, immunomodulatory, and neuroprotective properties, that can be valuable in this field. This review summarizes the major NDs and their pathophysiology, with a focus on the anti-neurodegenerative properties of cyanobacterial compounds and their main effects.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13101444