The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case–control study

Background Acetaminophen (APAP)-induced acute liver failure (ALF) is associated with significant mortality due to intracranial hypertension (ICH), a result of cerebral edema (CE) and astrocyte swelling. Brain-type fatty acid-binding protein (FABP7) is a small (15 kDa) cytoplasmic protein abundantly...

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Published in:Annals of intensive care 2017-10, Vol.7 (1), p.99-99, Article 99
Main Authors: Karvellas, Constantine J., Speiser, Jaime L., Tremblay, Mélanie, Lee, William M., Rose, Christopher F.
Format: Article
Language:English
Subjects:
ALFSG index
Analgesics
Anesthesiology
Critical Care Medicine
Drug overdose
Emergency Medicine
Intensive
Intensive care
Liver
Liver-type fatty acid-binding protein
Medical prognosis
Medicine
Medicine & Public Health
Mortality
Multiorgan failure
Prognosis
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Summary:Background Acetaminophen (APAP)-induced acute liver failure (ALF) is associated with significant mortality due to intracranial hypertension (ICH), a result of cerebral edema (CE) and astrocyte swelling. Brain-type fatty acid-binding protein (FABP7) is a small (15 kDa) cytoplasmic protein abundantly expressed in astrocytes. The aim of this study was to determine whether serum FABP7 levels early (day 1) or late (days 3–5) level were associated with 21-day mortality and/or the presence of ICH/CE in APAP-ALF patients. Methods Serum samples from 198 APAP-ALF patients (nested case–control study with 99 survivors and 99 non-survivors) were analyzed by ELISA methods and assessed with clinical data from the US Acute Liver Failure Study Group (ALFSG) Registry (1998–2014). Results APAP-ALF survivors had significantly lower serum FABP7 levels on admission (147.9 vs. 316.5 ng/ml, p  = 0.0002) and late (87.3 vs. 286.2 ng/ml, p  
ISSN:2110-5820
2110-5820
DOI:10.1186/s13613-017-0323-0