Reactivation of Hepatitis B virus in kidney transplant recipients with previous clinically resolved infection: A single-center experience

Hepatitis B virus (HBV) reactivation in kidney transplant recipients (KTR) involves important morbidity and mortality. Despite being more common in patients who are HBsAg-positive, it may occur in patients with clinically resolved infection (HBsAg-negative and anti-HBc-positive), in whom the presenc...

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Bibliographic Details
Published in:Nefrología 2018-09, Vol.38 (5), p.545-550
Main Authors: Meng, Catarina, Belino, Carolina, Pereira, Luciano, Pinho, Ana, Sampaio, Susana, Tavares, Isabel, Bustorff, Manuela, Sarmento, António, Pestana, Manuel
Format: Article
Language:English
Subjects:
Factores de riesgo
Hepatitis B
Infección
Infection
Kidney transplantation
Reactivación
Reactivation
Risk factors
Trasplante renal
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Summary:Hepatitis B virus (HBV) reactivation in kidney transplant recipients (KTR) involves important morbidity and mortality. Despite being more common in patients who are HBsAg-positive, it may occur in patients with clinically resolved infection (HBsAg-negative and anti-HBc-positive), in whom the presence of the protective anti-HB antibody is thought to decrease the risk of reactivation. Data regarding reactivation rates in this population are scarce. To retrospectively evaluate the risk of HBV reactivation in KTR with previously resolved infection. Retrospective cohort study including patients who underwent a kidney transplant between January 1994 and December 2014 with resolved HBV infection at the time of transplantation (anti-HBc seropositivity without detectable HBsAg, with or without anti-HB-positive antibodies and normal liver enzymes). Out of 966 patients, 95 patients with evidence of resolved HBV infection were analyzed, of which 86 had a titer of anti-HBs >10mIU/ml. Mean follow-up time was 93 months; 12 patients had lost anti-HBs. Two patients showed evidence of reactivation. Risk factors associated with loss of anti-HBs were elderly age (>60) and occurrence of acute graft rejection (p
ISSN:0211-6995
2013-2514
2013-2514
DOI:10.1016/j.nefro.2018.02.004