Outcomes of subjects who are lean, overweight or obese with nonalcoholic fatty liver disease: A cohort study in China

The ability to determine the prognosis of lean nonalcoholic fatty liver disease (NAFLD) is essential for decision making in clinical settings. Using a large community‐based Chinese cohort, we aimed to investigate NAFLD outcomes by body mass index (BMI). We used the restricted cubic splines method to...

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Bibliographic Details
Published in:Hepatology communications 2022-12, Vol.6 (12), p.3393-3405
Main Authors: Lan, Yanqi, Lu, Ying, Li, Jinfeng, Hu, Shiqi, Chen, Shuohua, Wang, Yanhong, Yuan, Xiaojie, Liu, Hongmin, Wang, Xiaomo, Wu, Shouling, Wang, Li
Format: Article
Language:English
Subjects:
Alcohol
Antigens
Blood pressure
Body mass index
Cardiovascular disease
China - epidemiology
Cohort analysis
Cohort Studies
Diabetes
Digestive system
Drug dosages
Enzymes
Esophageal cancer
Ethanol
Heart attacks
Hepatitis B
High density lipoprotein
Humans
Hypertension
Hypertension - complications
Liver diseases
Medical diagnosis
Mortality
Non-alcoholic Fatty Liver Disease - complications
Obesity
Obesity - complications
Original
Overweight
Overweight - complications
Population
Self report
Stroke
Vital statistics
Womens health
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Summary:The ability to determine the prognosis of lean nonalcoholic fatty liver disease (NAFLD) is essential for decision making in clinical settings. Using a large community‐based Chinese cohort, we aimed to investigate NAFLD outcomes by body mass index (BMI). We used the restricted cubic splines method to investigate the dose–response relationship between BMI and outcomes in subjects with NAFLD and those without NAFLD. We included 73,907 subjects from the Kailuan cohort and grouped all subjects into four phenotypes by using NAFLD and BMI (
ISSN:2471-254X
2471-254X
DOI:10.1002/hep4.2081