Induced Abortion, Birth Control Methods, and Breast Cancer Risk: A Case-Control Study in China

Background: The association between induced abortion and birth control methods (including oral contraceptives and intrauterine devices) and breast cancer may vary among countries, due to the different usage and frequency of birth control methods and induced abortion among countries. A better underst...

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Bibliographic Details
Published in:Journal of Epidemiology 2019/05/05, Vol.29(5), pp.173-179
Main Authors: Yuan, Xuelian, Yi, Fang, Hou, Can, Lee, Hui, Zhong, Xiaorong, Tao, Ping, Li, Hui, Xu, Zhuping, Li, Jiayuan
Format: Article
Language:English
Subjects:
Abortion
Birth control
Breast cancer
Cancer
case-control study
Confidence intervals
Contraceptives
Control methods
Demographics
Exposure
Health risk assessment
Health risks
Hormone replacement therapy
induced abortion
Intrauterine devices
IUD
Multivariate analysis
oral contraceptive
Oral contraceptives
Original
Regression analysis
Risk analysis
Risk factors
Risk management
Statistical analysis
Uterus
Womens health
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Summary:Background: The association between induced abortion and birth control methods (including oral contraceptives and intrauterine devices) and breast cancer may vary among countries, due to the different usage and frequency of birth control methods and induced abortion among countries. A better understanding of this association may help in determining safer birth control methods for Chinese women.Methods: A case-control study was conducted with a total of 794 cases and 805 controls. Standardized questionnaires were used to collect information on demographic characteristics, exposure to induced abortion, birth control methods, and other risk factors for breast cancer. Multivariate logistic regression was conducted to explore the association between birth control methods and breast cancer.Results: Multivariate logistic regression analyses showed that having a history of medical abortions, ≥3 surgical abortions, or both medical and surgical abortions was associated with an increased risk of breast cancer in post-menopausal women (odds ratio [OR] 2.48; 95% confidence interval [CI], 1.14–5.40). Pre-menopausal women who had used intra-uterine devices (IUDs) for more than 20 years tended to have a lower breast cancer risk than other age-matched pre-menopausal women (OR 0.41; 95% CI, 0.25–0.68). Both pre-menopausal and post-menopausal women who had
ISSN:0917-5040
1349-9092
DOI:10.2188/jea.JE20170318