Structural Mechanical Properties of 3D Printing Biomimetic Bone Replacement Materials

One of the primary challenges in developing bone substitutes is to create scaffolds with mechanical properties that closely mimic those of regenerated tissue. Scaffolds that mimic the structure of natural cancellous bone are believed to have better environmental adaptability. In this study, we used...

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Bibliographic Details
Published in:Biomimetics (Basel, Switzerland) Switzerland), 2023-04, Vol.8 (2), p.166
Main Authors: Lv, Xueman, Wang, Shuo, Xu, Zihe, Liu, Xuanting, Liu, Guoqin, Cao, Feipeng, Ma, Yunhai
Format: Article
Language:English
Subjects:
3-D printers
3D printing
Adaptability
Biocompatibility
Biomedical materials
Bone biomaterials
bone scaffold
Bones
Calcium phosphates
Cancellous bone
Composite materials
Finite element analysis
Finite element method
Fractures
Manufacturing
Mechanical properties
mechanical property analysis
PCL
Polymers
Pore size
Porosity
Production processes
Simulation
Skin & tissue grafts
TCP
Tissue engineering
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Summary:One of the primary challenges in developing bone substitutes is to create scaffolds with mechanical properties that closely mimic those of regenerated tissue. Scaffolds that mimic the structure of natural cancellous bone are believed to have better environmental adaptability. In this study, we used the porosity and thickness of pig cancellous bone as biomimetic design parameters, and porosity and structural shape as differential indicators, to design a biomimetic bone beam scaffold. The mechanical properties of the designed bone beam model were tested using the finite element method (FEM). PCL/β-TCP porous scaffolds were prepared using the FDM method, and their mechanical properties were tested. The FEM simulation results were compared and validated, and the effects of porosity and pore shape on the mechanical properties were analyzed. The results of this study indicate that the PCL/β-TCP scaffold, prepared using FDM 3D printing technology for cancellous bone tissue engineering, has excellent integrity and stability. Predicting the structural stability using FEM is effective. The triangle pore structure has the most stability in both simulations and tests, followed by the rectangle and honeycomb shapes, and the diamond structure has the worst stability. Therefore, adjusting the porosity and pore shape can change the mechanical properties of the composite scaffold to meet the mechanical requirements of customized tissue engineering.
ISSN:2313-7673
2313-7673
DOI:10.3390/biomimetics8020166