Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness

Wool fineness affects the quality of wool, and some studies have identified about forty candidate genes that affect sheep wool fineness, but these genes often reveal only a certain proportion of the variation in wool thickness. We further explore additional genes associated with the fineness of shee...

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Bibliographic Details
Published in:Animals (Basel) 2023-09, Vol.13 (18), p.2944
Main Authors: Zhang, Wentao, Jin, Meilin, Li, Taotao, Lu, Zengkui, Wang, Huihua, Yuan, Zehu, Wei, Caihong
Format: Article
Language:English
Subjects:
Androgens
Biological diversity
Cashmere
China
DNA sequencing
Economic development
Farm produce
Fst and θπ Ratio and XP-EHH
Genes
Genomes
Genomics
Morphology
Nucleotide sequencing
Quality control
Raw materials
selection signal
Sheep
Software
Textile fabrics
Transcription factors
whole-genome resequencing
Wool
wool fineness
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Summary:Wool fineness affects the quality of wool, and some studies have identified about forty candidate genes that affect sheep wool fineness, but these genes often reveal only a certain proportion of the variation in wool thickness. We further explore additional genes associated with the fineness of sheep wool. Whole-genome resequencing of eight sheep breeds was performed to reveal selection signals associated with wool fineness, including four coarse wool and four fine/semi-fine wool sheep breeds. Multiple methods to reveal selection signals (Fst and θπ Ratio and XP-EHH) were applied for sheep wool fineness traits. In total, 269 and 319 genes were annotated in the fine wool (F vs. C) group and the coarse wool (C vs. F) group, such as , , and and , , and . In F vs. C, 269 genes were enriched in 15 significant GO Terms ( < 0.05) and 38 significant KEGG Pathways ( < 0.05), such as protein localization to plasma membrane (GO: 0072659) and Inositol phosphate metabolism (oas 00562). In C vs. F, 319 genes were enriched in 21 GO Terms ( < 0.05) and 16 KEGG Pathways ( < 0.05), such as negative regulation of focal adhesion assembly (GO: 0051895) and Axon guidance (oas 04360). Our study has uncovered genomic information pertaining to significant traits in sheep and has identified valuable candidate genes. This will pave the way for subsequent investigations into related traits.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani13182944