Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture

Narrow maxilla is a common problem in orthodontics and dentofacial orthopedics. To solve this problem, a procedure called rapid maxillary expansion (RME) has been used. However, relapse tendency is a major problem of RME. Although relapse tendency is not clearly understood, various treatment procedu...

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Bibliographic Details
Published in:Drug design, development and therapy development and therapy, 2015, Vol.9 (Issue 1), p.6483-6488
Main Authors: Kazancioglu, Hakki Oguz, Aksakalli, Sertac, Ezirganli, Seref, Birlik, Muhammet, Esrefoglu, Mukaddes, Acar, Ahmet Hüseyin
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Bone formation
Bone growth
Bone regeneration
Caffeic acid
Caffeic Acids - administration & dosage
Caffeic Acids - pharmacology
CAPE
Defects
Health aspects
Histopathology
Incisors
Injections, Intraperitoneal
Male
Maxilla
Metabolism
Mid-palatal suture
Observations
Original Research
Orthodontics
Orthopedics
Osteogenesis
Osteogenesis - drug effects
Palatal Expansion Technique
Palate, Hard - drug effects
Palate, Hard - pathology
Phenols
Phenylethyl Alcohol - administration & dosage
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - pharmacology
Rapid Maxillary Expansion
Rats, Sprague-Dawley
Stainless steel
Time Factors
Wound healing
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Summary:Narrow maxilla is a common problem in orthodontics and dentofacial orthopedics. To solve this problem, a procedure called rapid maxillary expansion (RME) has been used. However, relapse tendency is a major problem of RME. Although relapse tendency is not clearly understood, various treatment procedures and new applications have been investigated. The present study aimed to investigate the possible effectiveness of caffeic acid phenethyl ester (CAPE) on new bone formation in rat midpalatal suture after RME. Twenty male Sprague Dawley rats were used in this study. The animals were randomly divided into two groups as control and CAPE group. In the CAPE group, CAPE was administered systemically via intraperitoneal injection. RME procedure was performed on all animals. For this purpose, the springs were placed on the maxillary incisors of rats and activated for 5 days. After then, the springs were removed and replaced with short lengths of rectangular retaining wire for consolidation period of 15 days. At the end of the study, histomorphometric analysis was carried out to assess new bone formation. New bone formation was significantly greater in the CAPE group than the control group (P
ISSN:1177-8881
1177-8881
DOI:10.2147/DDDT.S97797