Can one teaspoon of trehalose a day mitigate metabolic syndrome and diabetes risks?

The specific bond between the 2 glucose molecules of trehalose, however, impacts on its digestion rate, compared to maltose (a disaccharide of starch digestion), resulting in a slightly reduced absorption rate and consequently reduced glycemia, insulinemia and oxidation rate in energy metabolism, as...

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Bibliographic Details
Published in:Nutrition journal 2021-03, Vol.20 (1), p.28-28, Article 28
Main Authors: Brouns, Fred, Blaak, Ellen
Format: Article
Language:English
Subjects:
Blood glucose
Clinical trials
Diabetes
Diabetes mellitus
Digestion
Disaccharides
Dosage
Energy metabolism
Food intake
Glucose
Homeostasis
Hyperglycemia
Letter to the Editor
Maltose
Metabolic syndrome
Oxidation
Starch
Trehalose
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Summary:The specific bond between the 2 glucose molecules of trehalose, however, impacts on its digestion rate, compared to maltose (a disaccharide of starch digestion), resulting in a slightly reduced absorption rate and consequently reduced glycemia, insulinemia and oxidation rate in energy metabolism, as we have shown in humans at rest and during exercise [1,2,3,4]. [5] entitled “Daily consumption of one teaspoon of trehalose can help maintain glucose homeostasis: a double-blind, randomized controlled trial conducted in healthy volunteers”, raises a number of critical questions: * Neither a clear hypothesis nor a discussion is presented about why free glucose, derived from trehalose, would lead to a different response compared to glucose absorbed from other carbohydrate sources. * The authors failed to present a plausible mechanism explaining why glucose from trehalose is able to contribute to the prevention of pathologies that are predisposed to by postprandial hyperglycemia. * The dose ingested, 3,3 g (13,2 kcal)/day, along with the normal daily food intake, is so small that a measurable effect on blood glucose, hormones, metabolic fate and energy deposition can neither be expected, nor can be measured. Careful evaluation of the digestion, absorption and metabolism of trehalose substantiates that well controlled independent research is required before any conclusion can be drawn that the glucose absorbed from digested trehalose is able to impact on glucose homeostasis in favor of diabetes risk reduction.
ISSN:1475-2891
1475-2891
DOI:10.1186/s12937-021-00685-6