Gender differences in the association between the uric acid to high-density lipoprotein cholesterol ratio and diabetes risk: a mediation analysis of c-reactive protein, triglycerides, and insulin resistance

The uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a novel metabolic marker and is proven to be associated with diabetes risk. However, there is still a lack of systematic research regarding its role in gender differences and underlying mechanisms. This study aims to as...

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Published in:Lipids in health and disease 2024-12, Vol.23 (1), p.409-15, Article 409
Main Authors: Yin, Jianming, Zheng, Chuanjie, Li, Zhan, Chang, Ying, Cao, Lingyong, Qu, Yiqian
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Cholesterol
Cholesterol, HDL - blood
Diabetes
Diabetes Mellitus - blood
Diabetes Mellitus - epidemiology
Female
Health aspects
High density lipoproteins
Humans
Insulin Resistance
Male
Mediation Analysis
Medical research
Medicine, Experimental
Middle Aged
NHANES
Physiological aspects
Risk Factors
Sex Characteristics
Sex Factors
Triglycerides
Triglycerides - blood
UHR
Uric acid
Uric Acid - blood
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Summary:The uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a novel metabolic marker and is proven to be associated with diabetes risk. However, there is still a lack of systematic research regarding its role in gender differences and underlying mechanisms. This study aims to assess the association of UHR with diabetes risk in the context of gender differences and to investigate its mediation effects through metabolic and inflammatory pathways. This study utilized data from NHANES 2005-2010 and included 6,843 adult participants. Multivariate logistic regression was employed to assess the association between UHR and diabetes risk, and restricted cubic spline (RCS) along with correlation analysis was applied to explore its relationship with metabolic risk factors. Multiple mediation analysis was conducted to evaluate the mediating effects of homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides (TG), and C-reactive protein (CRP) on the association between UHR and diabetes risk. In the overall population, UHR was significantly positively associated with diabetes risk, but gender-stratified analysis revealed a stronger predictive effect in women. In the unadjusted model, every unit increase in UHR was linked to an 18.6% increase in diabetes risk in women (p 
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-024-02404-6