Body weight changes and longitudinal associations with cognitive decline among community‐dwelling older adults

Introduction We aim to investigate the longitudinal associations between changes in body weight (BW) and declines in cognitive function and risk of mild cognitive impairment (MCI)/dementia among cognitively normal individuals 65 years or older. Methods Data from the Age Gene/Environment Susceptibili...

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Published in:Alzheimer's & dementia : diagnosis, assessment & disease monitoring assessment & disease monitoring, 2021, Vol.13 (1), p.e12163-n/a
Main Authors: Eymundsdottir, Hrafnhildur, Ramel, Alfons, Geirsdottir, Olof G., Skuladottir, Sigrun S., Gudmundsson, Larus S., Jonsson, Palmi V., Gudnason, Vilmundur, Launer, Lenore, Jonsdottir, Maria K., Chang, Milan
Format: Article
Language:English
Subjects:
Adults
Age
Alzheimer's disease
APOE ε4
Blood pressure
Body mass index
body weight changes
Cognition & reasoning
Cognitive & Behavioral Assessment
Cognitive ability
cognitive function
Dementia
Executive function
Memory
memory function
mild cognitive impairment
Nutrition
Older people
Overweight
Risk factors
speed of processing
Vitamin D
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Summary:Introduction We aim to investigate the longitudinal associations between changes in body weight (BW) and declines in cognitive function and risk of mild cognitive impairment (MCI)/dementia among cognitively normal individuals 65 years or older. Methods Data from the Age Gene/Environment Susceptibility‐Reykjavik Study (AGES‐Reykjavik Study) including 2620 participants, were examined using multiple logistic regression models. Cognitive function included speed of processing (SP), executive function (EF), and memory function (MF). Changes in BW were classified as; weight loss (WL), weight gain (WG), and stable weight (SW). Results Mean follow‐up time was 5.2 years and 61.3% were stable weight. Participants who experienced WL (13.4%) were significantly more likely to have declines in MF and SP compared to the SW group. Weight changes were not associated with EF. WL was associated with a higher risk of MCI, while WG (25.3%) was associated with a higher dementia risk, when compared to SW. Discussion Significant BW changes in older adulthood may indicate impending changes in cognitive function.
ISSN:2352-8729
2352-8729
DOI:10.1002/dad2.12163