Tissue-specific increases in 11beta-hydroxysteroid dehydrogenase type 1 in normal weight postmenopausal women

With age and menopause there is a shift in adipose distribution from gluteo-femoral to abdominal depots in women. Associated with this redistribution of fat are increased risks of type 2 diabetes and cardiovascular disease. Glucocorticoids influence body composition, and 11beta-hydroxysteroid dehydr...

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Bibliographic Details
Published in:PloS one 2009-12, Vol.4 (12), p.e8475-e8475
Main Authors: Andersson, Therése, Simonyte, Kotryna, Andrew, Ruth, Strand, Magnus, Burén, Jonas, Walker, Brian R, Mattsson, Cecilia, Olsson, Tommy
Format: Article
Language:English
Subjects:
11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism
Adipose Tissue - enzymology
Adrenal Cortex Hormones - blood
Adrenal Cortex Hormones - urine
Adult
Aromatase - genetics
Aromatase - metabolism
Body Weight - physiology
Female
Gene Expression Regulation, Enzymologic
Humans
Lipids - blood
Liver - enzymology
Middle Aged
Organ Specificity - physiology
Postmenopause - blood
Postmenopause - physiology
Postmenopause - urine
RNA, Messenger - genetics
RNA, Messenger - metabolism
Subcutaneous Tissue - enzymology
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Summary:With age and menopause there is a shift in adipose distribution from gluteo-femoral to abdominal depots in women. Associated with this redistribution of fat are increased risks of type 2 diabetes and cardiovascular disease. Glucocorticoids influence body composition, and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) which converts inert cortisone to active cortisol is a putative key mediator of metabolic complications in obesity. Increased 11betaHSD1 in adipose tissue may contribute to postmenopausal central obesity. We hypothesized that tissue-specific 11betaHSD1 gene expression and activity are up-regulated in the older, postmenopausal women compared to young, premenopausal women. Twenty-three pre- and 23 postmenopausal, healthy, normal weight women were recruited. The participants underwent a urine collection, a subcutaneous adipose tissue biopsy and the hepatic 11betaHSD1 activity was estimated by the serum cortisol response after an oral dose of cortisone. Urinary (5alpha-tetrahydrocortisol+5beta-tetrahydrocortisol)/tetrahydrocortisone ratios were higher in postmenopausal women versus premenopausal women in luteal phase (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0008475